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AAAS ScienceMag.org Search Search X Advanced Search Contents News Careers Journals Menu Read our COVID-19 research and news. Autoimmunity promotor CD4 + T RM 17 cells become activated by inflammatory cytokines to produce IL-17A and thereby promote autoimmunity Christian Krebs/UKE Hamburg Complementing macrophage functions Pulmonary fungal infections generate heterogenous alveolar macrophage subpopulations Xu-Vanpala/ Previous issue A human monoclonal antibody shows potential to prevent or treat acute flaccid myelitis associated with enterovirus D68 infection Kara Jianing Fu/Purdue University June issue Microglia protect the brain from an intranasal VSV infection by cross-presenting neuronal antigen to antiviral CD8 + T cells Moseman et al ./ May issue A glycan-modified RSV nanoparticle vaccine displaying multimeric pre-F protein focuses antibody responses on neutralizing epitopes K. Swanson et al ./ COVID-19 Collection Click on the image to access a special collection that includes all of ’s COVID-19 papers Stanislav Krasilnikov\TASS via Getty Images Contents August 2020 Vol 5, Issue 50 Focus Resident T H 17 cells break bad” in kidney autoimmunity By Marcus Buggert 07 Aug 2020 Full Access Restricted Access Resident memory T H 17 cells (T RM 17 cells) are induced by microbial infections in kidneys and amplify renal autoimmunity. Abstract Full Text PDF Research Articles Pathogen-induced tissue-resident memory T H 17 (T RM 17) cells amplify autoimmune kidney disease By Christian F. Krebs , Daniel Reimers , Yu Zhao , Hans-Joachim Paust , Patricia Bartsch , Sarah Nuñez , Mariana V. Rosemblatt , Malte Hellmig , Christoph Kilian , Alina Borchers , Leon U. B. Enk , Michael Zinke , Martina Becker , Joanna Schmid , Stefanie Klinge , Milagros N. Wong , Victor G. Puelles , Constantin Schmidt , Tabea Bertram , Natascha Stumpf , Elion Hoxha , Catherine Meyer-Schwesinger , Maja T. Lindenmeyer , Clemens D. Cohen , Michael Rink , Christian Kurts , Sören Franzenburg , Friedrich Koch-Nolte , Jan-Eric Turner , Jan-Hendrik Riedel , Samuel Huber , Nicola Gagliani , Tobias B. Huber , Thorsten Wiech , Holger Rohde , Maria Rosa Bono , Stefan Bonn , Ulf Panzer , Hans-Willi Mittrücker 07 Aug 2020 Full Access Restricted Access CD4 + T RM 17 cells become activated by inflammatory cytokines to produce IL-17A and thereby promote autoimmunity. Editor’s Summary Abstract Full Text PDF Supplementary Materials Functional heterogeneity of alveolar macrophage population based on expression of CXCL2 By Shengjie Xu-Vanpala , M. Elizabeth Deerhake , Joshua D. Wheaton , Morgan E. Parker , Praveen R. Juvvadi , Nancie MacIver , Maria Ciofani , Mari L. Shinohara 07 Aug 2020 Full Access Restricted Access Pulmonary fungal infections generate heterogenous alveolar macrophage subpopulations. Editor’s Summary Abstract Full Text PDF Supplementary Materials Editors’ Choice The (inner) world according to GARP: Genetic susceptibility and regulatory T cells By Shiv Pillai 07 Aug 2020 Full Access Restricted Access A human autoimmune and allergic disease susceptibility variant on chromosome 11 results in the reduced expression of the gene encoding the GARP protein and thus compromises the function of regulatory T cells. Abstract Full Text More From Current Table of Contents First Release Papers Archive About Mission and Scope Editors and Advisory Board FOCIS Highlights Editorial Policies Information for Authors Information for Reviewers Contact Us Remote Access for Current Subscribers Editor’s Blog Subscribe Free Sample Articles Institutional Subscriptions Get the eTOC Alert Submit About The Cover ONLINE COVER Renal Memories of Past Infections. This month’s cover is an immunofluorescence image of a thin section of mouse kidney that includes a single glomerulus consisting of a tuft of capillary endothelial cells stained for endomucin (green). The glomerular capillaries are separated from epithelial lining cells positive for synaptopodin (pink) by the glomerular basement membrane, the kidney structure that allows for filtering of the blood. Krebs et al . found that mice infected systemically with Staphylococcus aureus followed with antibiotic treatment to clear the infection maintained a stable population of kidney-resident memory T cells capable of producing IL-17A. These renal T RM 17 cells could be reactivated during autoimmune kidney disease leading to exacerbated tissue damage. 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